Chromatography Standards
Medchemexpress LLC Fostamatinib Disodium | 1025687-58-4 | 98.3% | 25 MG
Fostamatinib Disodium is the oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).
- Oral proagent of active compound R406
- Orally available and competitive Syk/FLT3 inhibitor
- Inhibits Lyn and Lck
Medchemexpress LLC Econazole nitrate | 24169-02-6 | 98.0% | 25 G
Econazole nitrate is an imidazole class antifungal medication that also exhibits antibacterial activity. It is commonly used as a cream to treat various skin infections and has shown effectiveness in curing vaginal candidiasis via oral administration, with studies indicating it is generally well-tolerated.
- Imidazole class antifungal medication
- Exhibits antibacterial activity
- Treats skin infections such as athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch
- Cures vaginal candidiasis
- Generally well tolerated
Medchemexpress LLC Methocarbamol | 532-03-6 | 99.8% | 10 MM 1 ML
Methocarbamol is an orally active central muscle relaxant that blocks the muscular Nav1.4 channel. It reversibly affects the voltage dependence of inactivation of the Nav1.4 channel. This compound has potential for research into muscle spasms and pain syndromes. It is intended for research use only and not for patient administration.
- Blocks muscular Nav1.4 channel
- Reversibly affects voltage dependence of inactivation of Nav1.4 channel
- Potential for research into muscle spasms and pain syndromes
- Orally active central muscle relaxant
- Purity of 99.8%
- Molecular formula: C11H15NO5
- Molecular weight: 241.2405
- Storage for powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 2 years, -20°C for 1 year
Selleck Chemical LLC Cytarabine 50mg 147-94-4 Cytarabin, Ara-C, Arabinofuranosyl Cytidine
Cytarabine (Cytarabin, Ara-C, Arabinofuranosyl Cytidine) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Diclofenac ethyl ester | 15307-77-4 | 99.3% | 50 MG
Diclofenac ethyl ester is the prodrug of Diclofenac, encapsulated in polymer micelles in vitro. It is released with prolonged circulation time and reduced drug concentrations in the heart and kidneys in vivo.
- Prodrug of Diclofenac
- Encapsulated in polymer micelles
- Designed for prolonged circulation time
- Aids in reduced drug concentrations in heart and kidneys
- Targets COX
- Relevant to immunology and inflammation pathways
- Soluble in DMSO at 50 mg/mL (requires ultrasonic)
- Soluble in 10% DMSO and 90% corn oil for in vivo applications (≥ 2.5 mg/mL)
Medchemexpress LLC Lenvatinib-d4 (E7080-d4) | 2264050-65-7 | 99.6% | 430.88 | 50 MG
Lenvatinib-d4 is the deuterium-labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, and shows potent antitumor activities.
- Used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Bupropion morpholinol | 357399-43-0 | 99.7% | 10 MG
Bupropion morpholinol, also known as Hydroxy Bupropion, is a major metabolite of Bupropion. It functions by inhibiting Dopamine and Norepinephrine transporters, as well as the α4β2 nicotinic receptor in vitro. This compound plays a role in antidepressant and smoking cessation activities. It is produced from Bupropion in vivo by the genetically polymorphic enzyme CYP2B6. It inhibits [3H]norepinephrine uptake with an IC50 of 1.7 μM. This product is intended for research use only and is not sold to patients.
- Major metabolite of bupropion
- Inhibits dopamine and norepinephrine transporters
- Inhibits the α4β2 nicotinic receptor in vitro
- Contributes to antidepressant and smoking cessation activities
- Produced from bupropion by the genetically polymorphic enzyme CYP2B6 in vivo
- Inhibits [3H]norepinephrine uptake with an IC50 of 1.7 μM
- Intended for research use only
Apexbio Technology LLC Ivermectin 70288-86-7 10mM (in 1mL DMSO)
Ivermectin is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors ( 7 nAChR) and purinergic receptors (P2X4) Additionally ivermectin influences chloride ion channels regulated by glutamate and GABA and also enhances glycine receptor-mediated currents at low concentrations It is commonly employed in neuropharmacological research examining receptor function ion channel activity and neurotransmitter signaling pathways As an anthelmintic ivermectin is widely used in parasitology research for its inhibition of parasite neuromuscular transmission Reported IC50 values vary among receptor types generally ranging from nanomolar to micromolar levels depending on assay conditions and biological context
Medchemexpress LLC N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)butyramide | 198470-91-6 | 50mg
Palbociclib impurity 48 is an impurity of Palbociclib (HY-50767)
Apexbio Technology LLC Pantoprazole 102625-70-7 10mM (in 1mL DMSO)
Pantoprazole is an inhibitor of H /K -ATPase frequently utilized in biomedical research to explore mechanisms related to gastric acid secretion and intracellular acidification Upon acid-activated conversion to its sulfenamide derivative pantoprazole irreversibly binds to cysteine residues (Cys813 and Cys822) in gastric parietal cell proton pumps thus suppressing proton transport and subsequent acid secretion Pantoprazole also impairs lysosomal acidification with an IC50 value of approximately 194 M Its reported antimicrobial activity against Helicobacter pylori expands its experimental application making pantoprazole suitable in studies involving gastric physiology proton pump enzymology lysosomal function and bacterial pathogenesis
TARGETMOL CHEMICALS INC CLEVUDINE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly clevudine is phosphorylated to its active metabolites clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA) therefore the patient is less likely to have a relapse after treatment is discontinued. purity: 99%
Apexbio Technology LLC Folic acid 59-30-3 5g
Folic acid (CAS 59-30-3) is a water-soluble B9 vitamin structurally derived from Spinacia oleracea It functions as a cofactor in one-carbon transfer reactions facilitating nucleotide synthesis and methylation processes essential for DNA replication and cellular division Due to its involvement in folate metabolism folic acid is frequently utilized in studies of cell proliferation gene expression regulation and metabolic disorders For optimal stability folic acid should be stored in a sealed container under cool dry conditions
Sigma Aldrich Fine Chemicals Biosciences Everolimus European Pharma
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Medchemexpress LLC Fostamatinib disodium hexahydrate | 914295-16-2 | 99.5% | 50 MG
Fostamatinib disodium hexahydrate is an oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor, also inhibiting Lyn and Lck. This product is for research use only.
- Oral proagent of R406
- Orally available
- Competitive Syk/FLT3 inhibitor
- Inhibits Lyn and Lck
- For research use only
Medchemexpress LLC Rosuvastatin calcium | 147098-20-2 | MFCD04112702 | 99.8% | 500.57 g/mol | C22H27Ca0.5FN3O6S | 10 MG
Rosuvastatin calcium is the hemicalcium salt of rosuvastatin, a potent competitive HMG-CoA reductase inhibitor used in research to study cholesterol metabolism, lipid-lowering effects, and cardiac electrophysiology. Supplied as a solid and as DMSO solutions, it is used for in vitro assays exploring statin pharmacology and hERG-related effects.
- Competitive HMG-CoA reductase inhibitor (IC50 ≈ 11 nM).
- Potent blocker of hERG current (IC50 ≈ 195 nM).
- High purity: 99.77% (supplier listed).
- CAS number 147098-20-2.
- Supplied as powder and 10 mM in DMSO solution for in vitro use.
- Commonly used to study LDL and triglyceride reduction and electrophysiological effects.